Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase (IPR014190)

Short name: B4_12hDH

Family relationships



Leukotriene B4 12-hydroxydehydrogenase is an NADP-dependent enzyme of arachidonic acid metabolism, responsible for converting leukotriene B4 to the much less active metabolite 12-oxo-leukotriene B4. The BRENDA database lists leukotriene B4 12-hydroxydehydrogenase as one of the synonyms of 2-alkenal reductase (EC:, while EC: is 15-oxoprostaglandin 13-reductase.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0047522 15-oxoprostaglandin 13-oxidase activity
GO:0032440 2-alkenal reductase [NAD(P)] activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.