Arsenate reductase ArsC (IPR014064)

Short name: Arsenate_reductase_ArsC

Overlapping homologous superfamilies

Family relationships



This family describes the well-studied thioredoxin-dependent arsenate reductase of Staphylococcus aureus plasmid pI258 and other mechanistically similar arsenate reductases. The mechanism involves an intramolecular disulphide bond cascade, and aligned members of this family have four absolutely conserved Cys residues. This group of arsenate reductases belongs to the low-molecular weight protein-tyrosine phosphatase family, as does a group of glutathione/glutaredoxin type arsenate reductases (IPR014062). At least two other, non-homologous groups of arsenate reductases involved in arsenical resistance are also known. This enzyme reduces arsenate to arsenite, which may be more toxic but which is more easily exported [PMID: 12072565].

GO terms

Biological Process

GO:0046685 response to arsenic-containing substance

Molecular Function

GO:0030612 arsenate reductase (thioredoxin) activity
GO:0004725 protein tyrosine phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.