Domain

Mycoplasma arthritidis-derived mitogen, N-terminal (IPR014022)

Short name: M_arthritidis-der_mitogen_N

Domain relationships

None.

Description

Mycoplasma arthritidis-derived mitogen (MA-Mit) adopts a completely alpha-helical structure consisting of ten alpha helices arranged in two orthogongal bundles. MA-Mit is a superantigen that can activate large fractions of T cells bearing particular TCR V-beta elements. Two MA-Mit molecules form an asymmetric dimer and cross-link two MHC antigens to form a dimerised MA-Mit-MHC complex [PMID: 14962388]. This entry represents the N-terminal alpha-helical bundle domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D