Helicase/SANT-associated domain (IPR014012)

Short name: HSA_dom

Overlapping homologous superfamilies


Domain relationships



The helicase/SANT-associated (HSA) domain is a predicted DNA-binding domain of ~75 amino acids [PMID: 11779830], which is found in the eukaryotic SRCAP/p400/DOM and SNF2/brahma families [PMID: 16024792]. While each family has the core sequences that define the HSA domain, they each also have additional sequences that distinguish these families from one another. For example, the sequence HWDY(L/C)EEEM(Q/V) is found in the SRCAP/p400/DOM family, whereas the sequence HQE(Y/F)LNSILQ is found in the SNF2 /brahma family [PMID: 16024792]. In addition to the SANT and helicase domains, the HSA domain is also found in association with the bromo domain [PMID: 11779830].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles