Domain

REJ domain (IPR014010)

Short name: REJ_dom

Domain relationships

None.

Description

The REJ domain is an extracellular module of ~700 amino acids, which is found associated with other domains, such as EGF, the GPS proteolytic cleavage site, C-type lectin, SUEL-type lectin, LRR, LDL-A, PLAT, PKD [PMID: 8666666, PMID: 9285785]. Although its function is unknown, the REJ domain has been shown to be required for cleavage to occur at the GPS [PMID: 12482949]. It has been proposed that the REJ domain might function in ion transport homeostasis [PMID: 8666666].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles