Pathways & interactions
Aldehyde ferredoxin oxidoreductase, N-terminal (IPR013983)
Short name: Ald_Fedxn_OxRdtase_N
Overlapping homologous superfamilies
Enzymes of the aldehyde ferredoxin oxidoreductase (AOR) family [PMID: 9242907] contain a tungsten cofactor and an 4Fe4S cluster and catalyse the interconversion of aldehydes to carboxylates [PMID: 8672295]. This family includes AOR, formaldehyde ferredoxin oxidoreductase (FOR), glyceraldehyde-3-phosphate ferredoxin oxidoreductase (GAPOR), all isolated from hyperthermophilic archea [PMID: 9242907]; carboxylic acid reductase found in clostridia [PMID: 2550230]; and hydroxycarboxylate viologen oxidoreductase from Proteus vulgaris, the sole member of the AOR family containing molybdenum [PMID: 8026480]. GAPOR may be involved in glycolysis [PMID: 7721730], but the functions of the other proteins are not yet clear. AOR has been proposed to be the primary enzyme responsible for oxidising the aldehydes that are produced by the 2-keto acid oxidoreductases [PMID: 9275170].
This entry represents the N-terminal domain of these enzymes. This domain has been shown to interact with the tungsten cofactor [PMID: 7878465].
GO:0055114 oxidation-reduction process
No terms assigned in this category.