Family

E3 ubiquitin ligase Bre1 (IPR013956)

Short name: E3_ubiquit_lig_Bre1

Family relationships

None.

Description

Bre1 is an E3 ubiquitin ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme Rad6/Ubc2 [PMID: 12535539].

This entry also includes Bre1 homologues from fission yeasts, Brl1 and Brl2. They are E3 ubiquitin-protein ligase components of the multisubunit protein complex (termed HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1 [PMID: 17363370].

GO terms

Biological Process

GO:0010390 histone monoubiquitination

Molecular Function

GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER