Family

E3 ubiquitin ligase Bre1 (IPR013956)

Short name: E3_ubiquit_lig_Bre1

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Bre1 is an E3 ubiquitin ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme Rad6/Ubc2 [PMID: 12535539].

This entry also includes Bre1 homologues from fission yeasts, Brl1 and Brl2. They are E3 ubiquitin-protein ligase components of the multisubunit protein complex (termed HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1 [PMID: 17363370].

GO terms

Biological Process

GO:0010390 histone monoubiquitination

Molecular Function

GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER