Domain

FACT complex subunit Spt16 domain (IPR013953)

Short name: FACT_Spt16

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

Proteins in this entry are subunits the FACT complex; the FACT complex is a stable heterodimer in Saccharomyces cerevisiae comprising Spt16 and Pob3. The complex plays a role in transcription initiation and promotes binding of TATA-binding protein (TBP) to a TATA box in chromatin [PMID: 15987999]; it also facilitates RNA polymerase II transcription elongation through nucleosomes by destabilising and then reassembling nucleosome structure [PMID: 12524332, PMID: 12934006].

The proteins in this entry are non-peptidase homologues belonging to MEROPS peptidase family M24 (clan MG).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam