Family

CGI121/TPRKB (IPR013926)

Short name: CGI121/TPRKB

Family relationships

Description

This entry represents the EKC/KEOPS complex subunit Cgi121 from fungi and its homologue, TPRKB from mammals. Interestingly, this family also includes archaeal homologues [PMID: 18951093].

CGI121 is part of the KEOPS complex, which is involved in is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine [PMID: 21183954]. The KEOPS complex also plays an important part in telomere uncapping and telomere elongation [PMID: 16564010]. The complex is required for efficient recruitment of transcriptional coactivators [PMID: 16564010].

TPRKB has been shown to bind to the p53-related protein kinase (PRPK) [PMID: 12659830]. PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
PANTHER
Pfam
SUPERFAMILY