Family

CGI121/TPRKB (IPR013926)

Short name: CGI121/TPRKB

Family relationships

Description

This entry represents the EKC/KEOPS complex subunit Cgi121 from fungi and its homologue, TPRKB from mammals. Interestingly, this family also includes archaeal homologues [PMID: 18951093].

CGI121 is part of the KEOPS complex, which is involved in is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine [PMID: 21183954]. The KEOPS complex also plays an important part in telomere uncapping and telomere elongation [PMID: 16564010]. The complex is required for efficient recruitment of transcriptional coactivators [PMID: 16564010].

TPRKB has been shown to bind to the p53-related protein kinase (PRPK) [PMID: 12659830]. PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam