Ribonuclease H2, subunit C (IPR013924)

Short name: RNase_H2_suC

Overlapping homologous superfamilies


Family relationships



Whereas bacterial and archaeal RNases H2 are active as single polypeptides, eukaryotic RNase H2 is a heterotrimeric complex of the RNase H2A, RNase H2B, and RNase H2C proteins that are all required for proper function and activity PMID: 14734815, PMID: 19923215]. RNase H2 is an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. It participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication.

This entry represents the non-catalytic C subunit of RNase H2.

GO terms

Biological Process

GO:0006401 RNA catabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0032299 ribonuclease H2 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.