Nuclear-interacting partner of ALK/Rsm1-like (IPR013909)

Short name: NIPA/Rsm1

Domain relationships



This entry contains Nuclear-interacting partner of ALK (NIPA) and NIPA like proteins, as well as mRNA export factor Rsm1, all of which contain a C3HC-type zinc finger. The domain represented in this entry is found C-terminal to the zinc-finger like domain IPR012935. Rsm1 is involved in mRNA export from the nucleus [PMID: 15357289]. NIPA is an essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry [PMID: 16009132].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.