Domain

Lethal giant larvae (Lgl)-like, C-terminal domain (IPR013905)

Short name: Lgl_C_dom

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The Lethal giant larvae (Lgl) tumour suppressor protein is conserved from yeast to mammals. The Lgl protein functions in cell polarity, at least in part, by regulating SNARE-mediated membrane delivery events at the cell surface [PMID: 15964280]. The N-terminal half of Lgl members contains WD40 repeats (see IPR001680), while the C-terminal half appears specific to the protein [PMID: 15964280].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam