Domain

DNA endonuclease Ctp1, C-terminal (IPR013882)

Short name: Ctp1_C

Domain relationships

None.

Description

This entry represents the C-terminal domain of the fission yeast Ctip protein. Proteins containing this domain include DNA endonuclease RBBP8 from animals and protein gamma response 1 (GR1) from Arabidopsis [PMID: 11023598]. However, this entry does not include Sae2 from Saccharomyces cerevisiae.

RBBP8 is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends [PMID: 17965729]. Ctp1 is an endonuclease that cooperates with the MRN complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of rec12 from the break sites and ensuring both resection and intrachromosomal association of the broken ends [PMID: 17936710].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0004519 endonuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam