Domain

TFIIH p62 subunit, N-terminal (IPR013876)

Short name: TFIIH_BTF_p62_N

Domain relationships

  • PH domain-like (IPR011993)
    • TFIIH p62 subunit, N-terminal (IPR013876)

Description

The N-terminal region of the TFIIH basal transcription factor complex p62 subunit (BTF2-p62) forms an interaction with the 3' endonuclease XPG, which is essential for activity. The 3' endonuclease XPG is a major component of the nucleotide excision repair machinery. The structure of the N-terminal region reveals that it adopts a pleckstrin homology (PH) fold [PMID: 15195146, PMID: 15909982].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam