Domain

Cysteine-rich secretory protein (IPR013871)

Short name: Cysteine_rich_secretory

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry is found on Crisp proteins which contain IPR001283 and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling [PMID: 16339766]. It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK [PMID: 16339766].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam