Domain

Cdc37, N-terminal domain (IPR013855)

Short name: Cdc37_N_dom

Domain relationships

None.

Description

Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This entry corresponds to the N-terminal kinase binding domain of these proteins [PMID: 16098195]. It is found N-terminal to a Hsp90 chaperone (heat shock protein 90) binding domain (IPR013874). Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 has been shown to result in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function [PMID: 16098195].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0019901 protein kinase binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART