Transcription factor Otx, C-terminal (IPR013851)

Short name: Otx_TF_C

Overlapping homologous superfamilies


Domain relationships



Otx proteins constitute a class of vertebrate homeodomain-containing transcription factors that have been shown to be essential for anterior head formation, including brain morphogenesis. They are orthologous to the product of the Drosophila head gap gene, orthodenticle (Otd), and appear to play similar roles in both, since the developmental abnormalities caused by disruption of these transcription factors in one, can be recovered by substitution of the factor(s) from the other. Such studies have provided strong evidence that there exists a conserved genetic programme for insect and mammalian brain development, which presumably arose in a more primitive common ancestor [PMID: 10199636, PMID: 10440864].

Two vertebrate orthodenticle-related transcription factors have been indentified, Otx1 and Otx2, which have sizes of 355 and 289 residues respectively. They contain a bicoid-like homeodomain, which features a conserved lysine residue at position 9 of the DNA recognition helix, which is thought to confer high-affinity binding to TAATCC/T elements on DNA [PMID: 10375352]. Otd-like transcription factors have also been found in zebrafish and certain lamprey species.

This entry represents a conserved region found in the C-terminal region of these proteins.

GO terms

Biological Process

GO:0007275 multicellular organism development

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.