mRNA capping enzyme, C-terminal (IPR013846)

Short name: mRNA_cap_enzyme_C

Overlapping homologous superfamilies

Domain relationships



This domain is found at the C terminus of the mRNA capping enzyme. The mRNA capping enzyme in yeasts is composed of two separate chains: alpha a mRNA guanyltransferase and beta an RNA 5'-triphosphate. X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes [PMID: 9160746]. Binding of the enzyme to nucleotides is specific to the GMP moiety of GTP. The viral mRNA capping enzyme is a monomer that transfers a GMP cap onto the end of mRNA that terminates with a 5'-diphosphate tail.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.