Binding Site

Beta tubulin, autoregulation binding site (IPR013838)

Short name: Beta-tubulin_BS

Description

The stability of beta-tubulin mRNAs are autoregulated by their own translation product [PMID: 3072712]. Unpolymerised tubulin subunits bind directly (or activate a factor(s) which binds co-translationally) to the nascent N terminus of beta-tubulin. This binding is transduced through the adjacent ribosomes to activate an RNAse that degrades the polysome-bound mRNA. The recognition element has been shown to be the first four amino acids of beta-tubulin: Met-Arg-Glu-Ile. Mutations to this sequence abolish the autoregulation effect (except for the replacement of Glu by Asp); transposition of this sequence to an internal region of a polypeptide also suppresses the autoregulatory effect.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns