SGNH hydrolase-type esterase domain (IPR013830)

Short name: SGNH_hydro

Overlapping homologous superfamilies

Domain relationships


This entry represents the SGNH hydrolase-type esterase domain, which has a similar fold to flavoproteins, namely a three-layer alpha/beta/alpha structure, where the beta-sheets are composed of five parallel strands. Enzymes containing this domain act as esterases and lipases, but have little sequence homology to true lipases [PMID: 10801485, PMID: 15522763]. Proteins containing this type of esterase domain have been found in a variety of hydrolases; those with structural information include an esterase from Streptomyces scabies [PMID: 7773790]; the esterase domain of viral haemagglutinin-esterase surface glycoproteins (influenza C virus, coronaviruses and toroviruses) [PMID: 9817207]; mammalian acetylhydrolases [PMID: 11522926]; fungal rhamnogalacturonan acetylesterase [PMID: 11752785]; and the multifunctional enzyme thioesterase I (TAP) from Escherichia coli [PMID: 12842470]. SGNH hydrolase-type esterase domains contain unique hydrogen bond network that stabilises their catalytic centres; they usually contain the catalytic triad Ser/Acid/His.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.