Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain (IPR013812)

Short name: Glyco_hydro_2/20_Ig-like

Domain relationships


O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

Glycoside hydrolase family 2 GH2 comprises enzymes with several known activities: beta-galactosidase (EC:; beta-mannosidase (EC:; beta-glucuronidase (EC:

Glycoside hydrolase family 20 GH20 consists of enzymes such as chitobiases and beta-hexosaminidases (EC:, in which this immunoglobulin-like domain occurs at the C terminus [PMID: 8673609, PMID: 8008071].

This entry describes the immunoglobulin-like beta-sandwich domain that consists of seven beta-strands in two sheets with a Greek-key topology, although some members may have extra strands. This fold is found in domains of glycoside hydrolase families 2 and 20. The function of this domain is unknown.

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.