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Overview
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Pathways & interactions
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Cross-references
Dwarfin (IPR013790)
Short name: Dwarfin
Overlapping homologous superfamilies
None.
Family relationships
None.
Description
This family of proteins was first identified in Caenorhabditis elegans. Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth [PMID: 8799132]. The dwarfin family also includes the Drosophila protein MAD that is required for the function of decapentaplegic (DPP) and may play a role in DPP signalling. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Dpp [PMID: 9230443].
GO terms
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Molecular Function
No terms assigned in this category.
Cellular Component
GO:0005622 intracellular
Contributing signatures
- PTHR13703 (PTHR13703)