Dwarfin (IPR013790)

Short name: Dwarfin

Overlapping homologous superfamilies

Family relationships



This family of proteins was first identified in Caenorhabditis elegans. Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth [PMID: 8799132]. The dwarfin family also includes the Drosophila protein MAD that is required for the function of decapentaplegic (DPP) and may play a role in DPP signalling. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Dpp [PMID: 9230443].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005622 intracellular

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.