Glycoside hydrolase, catalytic domain (IPR013781)

Short name: Glyco_hydro_catalytic_dom

Domain relationships


O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

This entry represents the catalytic TIM beta/alpha barrel common to many different families of glycosyl hydrolases. Structures have been determined for several proteins containing this domain, including family 13 glycosyl hydrolases (such as alpha-amylase) [PMID: 11914097], beta-glycanases [PMID: 14668328], family 1 glycosyl hydrolases (such as beta-glucosidase) [PMID: 10978344], type II chitinases [PMID: 11846790], 1,4-beta-N-acetylmuraminidases [PMID: 11427528], and beta-N-acetylhexosaminidases [PMID: 12171933].

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.