Domain

GHMP kinase, C-terminal domain (IPR013750)

Short name: GHMP_kinase_C_dom

Domain relationships

None.

Description

This domain is found in homoserine kinases (EC:2.7.1.39), galactokinases (EC:2.7.1.6) and mevalonate kinases (EC:2.7.1.36). These kinases make up the GHMP kinase superfamily of ATP-dependent enzymes [PMID: 8382990]. These enzymes are involved in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. The C-terminal domain of homoserine kinase has a central alpha-beta plait fold and an insertion of four helices, which, together with the N-terminal fold, create a novel nucleotide binding fold [PMID: 11188689].

This domain is also found in some diphosphomevalonate decarboxylases, which are structurally related members of the GHMP superfamily [PMID: 17583736], but do not possess kinase activity.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
Pfam
SUPERFAMILY