Fyv7/TAP26 (IPR013730)

Short name: Fyv7/TAP26

Overlapping homologous superfamilies


Family relationships


This entry include proteins from the FYV7 and the TAP26 families [PMID: 12837249].

FYV7 is involved in the processing of 20S pre-rRNA during the maturation of SSU-rRNA from tricistronic RNA transcripts (SSU-rRNA, 5.8S rRNA, LSU-rRNA). The SSU (small subunit) processome is required for production of the small ribosomal subunit RNA, the 18S rRNA [PMID: 12242301]. Fyv7 may also be required for survival upon K1 Killer toxin exposure.

Thyroid transcription factor 1-associated protein 26 (TAP26, also known as BR22) is a component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). It enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities [PMID: 12882447, PMID: 16630564].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.