Multiprotein bridging factor 1, N-terminal (IPR013729)

Short name: MBF1_N

Overlapping homologous superfamilies


Domain relationships



This domain is found in the multiprotein bridging factor 1 (MBF1) which forms a heterodimer with MBF2. It has been shown to make direct contact with the TATA-box binding protein (TBP) and interacts with Ftz-F1, stabilising the Ftz-F1-DNA complex [PMID: 9207077]. It is also found in the endothelial differentiation-related factor (EDF-1). Human EDF-1 is involved in the repression of endothelial differentiation, interacts with CaM and is phosphorylated by PKC [PMID: 11587857]. The domain is found in a wide range of eukaryotic proteins including metazoans, fungi and plants. A helix-turn-helix motif (IPR001387) is found to its C terminus.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.