Exportin-2, central domain (IPR013713)

Short name: XPO2_central

Overlapping homologous superfamilies

Domain relationships



Exportin-2, also known as CAS, is an export receptor for importin-alpha [PMID: 9323134]. It binds strongly to importin alpha only in the presence of RanGTP, forming an importin alpha/CAS/RanGTP complex. Exportin-2 mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm [PMID: 10394916].

This domain is found in exportin-2 and related proteins, such as exportin-7/8. This domain contains HEAT repeats.

GO terms

Biological Process

GO:0006886 intracellular protein transport

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.