Domain

Shikimate dehydrogenase substrate binding, N-terminal (IPR013708)

Short name: Shikimate_DH-bd_N

Domain relationships

None.

Description

This domain is the substrate binding domain of shikimate dehydrogenase [PMID: 15735308]. Shikimate dehydrogenase catalyses the fourth step of the mycobacterial Shikimate pathway, which results in the biosynthesis of chorismate. Chorismate is a precursor of aromatic amino acids, naphthoquinones, menaquinones and mycobactins [PMID: 18260104, PMID: 12637497]. This pathway is an important target for antibacterial agents, especially against Mycobacterium tuberculosis, since it does not occur in mammals.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004764 shikimate 3-dehydrogenase (NADP+) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam