Aflatoxin regulatory protein (IPR013700)

Short name: AflR

Overlapping homologous superfamilies


Domain relationships



Aflatoxins belong to a family of decaketides that are produced as secondary metabolites by Aspergillus flavus and Aspergillus parasiticus [PMID: 8074521]. The aflatoxin biosynthetic pathway involves several enzymatic steps that appear to be regulated by the aflR genes in A. flavus and A. parasiticus. AflR encodes a protein that contains a cysteine-rich motif. Several fungal transcriptional activator proteins contain this motif, which binds DNA in a zinc-dependent fashion (occurs in fungal transcriptional regulatory proteins) [PMID: 1557122, PMID: 2107541].

This domain is found in the aflatoxin regulatory protein (AflR) which is involved in the regulation of the biosynthesis of aflatoxin in the fungal genus Aspergillus [PMID: 9758790]. It occurs together with the fungal Zn(2)-Cys(6) binuclear cluster domain (IPR001138).

This entry also includes Sterigmatocystin biosynthesis regulatory protein [PMID: 8662194]. Sterigmatocystin is related to aflatoxin.

GO terms

Biological Process

GO:0045122 aflatoxin biosynthetic process
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.