Squalene epoxidase (IPR013698)

Short name: Squalene_epoxidase

Overlapping homologous superfamilies


Domain relationships



This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria. SE was first cloned from Saccharomyces cerevisiae (Baker's yeast) where it was named ERG1. It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway [PMID: 9161422]. Putative transmembrane regions are found to the protein's C terminus.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0050660 flavin adenine dinucleotide binding
GO:0004506 squalene monooxygenase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.