Domain

VIT domain (IPR013694)

Short name: VIT

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The inter-alpha-trypsin inhibitor (ITI) family is composed of protease inhibitors that are assembled from two precursor proteins: a light chain and different homologous heavy chains (ITIHs). Originally identified as plasma inhibitors, recent data indicate that ITI plays a role in extracellular matrix stabilisation and in prevention of tumour metastasis [PMID: 14744536].

Two domains are conserved in all known ITIHs, the vault protein inter-alpha- trypsin (VIT) domain and a von Willebrand type A (vWA) domain. The VIT domain is less widespread than the vWA domain and is not genetically mobile. Therefore, it can be regarded as the characteristic domain of the ITIH family. The VIT domain is approximately 135 amino acids long. Its N-terminal part contains a pattern of hydrophobic residues, interrupted by a conserved arginine. The C terminus is best characterised by its conserved aromatic residues. In the central part, an acidic amino acid resides between two basic residues [PMID: 14744536].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam
Pfam
SMART