Domain

Mitochondrial Rho-like (IPR013684)

Short name: MIRO-like

Domain relationships

  • Mitochondrial Rho-like (IPR013684)

Description

Mitochondrial Rho proteins (Miro-1, Q8IXI2 and Miro-2, Q8IXI1) are atypical Rho GTPases. They have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (IPR002048), that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis [PMID: 12482879].

GO terms

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0005525 GTP binding

Cellular Component

GO:0005622 intracellular

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam