Calcium-activated chloride channel, N-terminal (IPR013642)

Short name: CLCA_N

Overlapping homologous superfamilies


Domain relationships



The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells [PMID: 11896056] and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors [PMID: 15284223]. This protein cleaves itself into an N-terminal portion and a C-terminal portion. The N terminus contains an HEXXHXXXGXXDE motif which is essential for proteolytic cleavage [PMID: 22350745, PMID: 23112050].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.