siRNA-mediated silencing protein NRDE-2 (IPR013633)

Short name: NRDE-2

Overlapping homologous superfamilies


Family relationships



Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that regulate heterochromatin formation, developmental timing, defence against parasitic nucleic acids, and genome rearrangement. Many small regulatory RNAs are thought to function in nuclei, and in plants and fungi small interfering RNAs (siRNAs) associate with nascent transcripts and direct chromatin and/or DNA modifications. NRDE-2, is required for siRNA-mediated silencing in nuclei. NRDE-2 associates with the Argonaute protein NRDE-3 within nuclei and is recruited by NRDE-3/siRNA complexes to nascent transcripts that have been targeted by RNA interference, RNAi, the process whereby double-stranded RNA directs the sequence-specific degradation of mRNA [PMID: 20543824].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.