Domain

MAP2/Tau projection (IPR013588)

Short name: MAP2_projctn

Domain relationships

None.

Description

This domain is found in the microtubule-associated protein 2 (MAP2)/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologues. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (IPR001084), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport [PMID: 15642108, PMID: 11576531].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam