Domain

SEFIR (IPR013568)

Short name: SEFIR

Domain relationships

None.

Description

This domain is found in IL17 receptors (IL17Rs, e.g. Q60943) and SEF proteins (e.g. Q8QHJ9). The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (IPR000157), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways [PMID: 12765832].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE profiles