tRNA(Met) cytidine acetyltransferase TmcA, N-terminal (IPR013562)

Short name: TmcA_N

Overlapping homologous superfamilies


Domain relationships



This entry represents a domain found in the N terminus of the bacterial tRNA(Met) cytidine acetyltransferase TmcA. TmcA catalyses the formation of N(4)-acetylcytidine (ac4C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and either ATP or GTP [PMID: 18668122]. This modification is thought to ensure precise recognition of the AUG codon by strengthening C-G base-pair interaction and also prevent misrecognition of the near cognate AUA codon [PMID: 19322199].

This domain can also be found in mammalian N-acetyltransferase 10 (NAT10) and fungal protein Kre33. Kre33 and NAT10 are RNA cytosine acetyltransferases with specificity toward both 18S rRNA and tRNAs [PMID: 25653167, PMID: 25402480].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.