Prolyl 4-hydroxylase alpha-subunit, N-terminal (IPR013547)

Short name: Pro_4_hyd_alph_N

Overlapping homologous superfamilies


Domain relationships



The members found in this entry are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC: is important in the post-translational modification of collagen, as it catalyses the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase [PMID: 7753822, PMID: 14500733, PMID: 2552442, PMID: 11850189]. The function of the N-terminal region featured in this family does not seem to be known.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0004656 procollagen-proline 4-dioxygenase activity

Cellular Component

GO:0005783 endoplasmic reticulum

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.