Domain

DNA mismatch repair protein, S5 domain 2-like (IPR013507)

Short name: DNA_mismatch_S5_2-like

Overlapping homologous superfamilies

Domain relationships

None.

Description

This domain is found in MutL and homologues and is characterized by a ribosomal protein S5 domain 2-like fold [PMID: 26249686].

The dimeric MutL protein has a key function in communicating mismatch recognition by MutS to downstream repair processes. Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex [PMID: 14527292].

GO terms

Biological Process

GO:0006298 mismatch repair

Molecular Function

GO:0005524 ATP binding
GO:0030983 mismatched DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam