Family

ATP-dependent Clp protease ATP-binding subunit ClpA (IPR013461)

Short name: ClpA

Family relationships

  • ClpA/B family (IPR001270)
    • ATP-dependent Clp protease ATP-binding subunit ClpA (IPR013461)

Description

Proteins in this entry are related to ClpA (P0ABH9) from Escherichia coli. ClpA is an ATP-dependent chaperone and part of the ClpAP protease that participates in regulatory protein degradation and the dissolution and degradation of protein aggregates [PMID: 2186030]. ClpA recognises sequences in specific proteins, which it then unfolds in an ATP-dependent manner and transports into the degradation chamber of the associated ClpP protein [PMID: 10485712, PMID: 11287666]. A small adaptor-like protein, ClpS, modulates the activity of ClpA and is an important regulatory factor for this protein [PMID: 12235156]. It protects ClpA from autodegradation and appears to redirect its activity away from soluble proteins and toward aggregated proteins.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004176 ATP-dependent peptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs