ATP-dependent Clp protease ATP-binding subunit ClpA (IPR013461)

Short name: ClpA

Overlapping homologous superfamilies

Family relationships

  • ClpA/B family (IPR001270)
    • ATP-dependent Clp protease ATP-binding subunit ClpA (IPR013461)


Proteins in this entry are related to ClpA (P0ABH9) from Escherichia coli. ClpA is an ATP-dependent chaperone and part of the ClpAP protease that participates in regulatory protein degradation and the dissolution and degradation of protein aggregates [PMID: 2186030]. ClpA functions as the regulatory component of the ATP dependent protease complex ClpAP [PMID: 28824920]. ClpA recognises sequences in specific proteins, which it then unfolds in an ATP-dependent manner and transports into the degradation chamber of the associated ClpP protease [PMID: 10485712, PMID: 11287666]. A small adaptor-like protein, ClpS, modulates the activity of ClpA and is an important regulatory factor for this protein [PMID: 12235156]. It protects ClpA from autodegradation and appears to redirect its activity away from soluble proteins and toward aggregated proteins.

GO terms

Biological Process

GO:0043335 protein unfolding

Molecular Function

GO:0016887 ATPase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.