Glucose-1-phosphate cytidylyltransferase (IPR013446)

Short name: G1P_cyt_trans

Overlapping homologous superfamilies

Family relationships



Alpha-D-Glucose-1-phosphate cytidylyltransferase, also known as CDP-glucose pyrophosphorylase, is the product of the rfbF gene and produces CDP-D-glucose from alpha-D-Glucose-1-phosphate and MgCTP as substrate [PMID: 15292268, PMID: 8144449, PMID: 15634670]. CDP-D-Glucose is the precursor for synthesizing four of the five naturally occurring 3,6-dideoxy sugars-abequose (3,6-dideoxy-D-Xylo-hexose), ascarylose (3,6-dideoxy-L-arabino-hexose), paratose (3,6-dideoxy-D-ribohexose), and tyvelose (3,6-dideoxy-D-arabino-hexose. Deoxysugars are ubiquitous in nature where they function in a variety of biological processes, including cell adhesion, immune response, determination of ABO blood groups, fertilization, antibiotic function, and microbial pathogenicity [PMID: 10406840].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0047343 glucose-1-phosphate cytidylyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • cd02524 (G1P_cytidylyltransferase)