Probable peptidoglycan glycosyltransferase FtsW (IPR013437)

Short name: FtsW

Overlapping homologous superfamilies


Family relationships


FtsW is an integral membrane protein with ten transmembrane segments [PMID: 15576787]. In general, it is one of two paralogues involved in peptidoglycan biosynthesis, the other being RodA, and is essential for cell division [PMID: 9218774]. In endospore-forming bacteria (e.g. Bacillus subtilis) three or more RodA/FtsW/SpoVE family paralogues are present [PMID: 9622350, PMID: 27895631]. SpoVE acts in spore cortex formation and is dispensable for growth [PMID: 1391053, PMID: 12626683].

FtsW belongs to the so called SEDS (shape, elongation, division and sporulation) family, which are thought to be peptidoglycan polymerases [PMID: 27525505].

GO terms

Biological Process

GO:0051301 cell division
GO:0009252 peptidoglycan biosynthetic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.