Muconate/chloromuconate cycloisomerase (IPR013370)

Short name: Chloromuconate_cycloisomerase

Overlapping homologous superfamilies

Family relationships



This family consists of muconate cycloisomerase (or Muconate Lactonizing Enzyme (MLE); EC: and chloromuconate cycloisomerase (or chloromuconate lactonizing enzymes (Cl-MLEs); EC:, enzymes that often overlap in specificity. It does not include more distantly related proteins such as mandelate racemase (EC:

MLE, a homooctameric enzyme, catalyses the conversion of cis,cis-muconate to muconolactone in the catechol branch of the beta-ketoadipate pathway [PMID: 8905091, PMID: 4599397]. This pathway is used in soil microbes to breakdown lignin-derived aromatics, catechol and protocatechuate, to citric acid cycle intermediates. Some bacterial species are also capable of dehalogenating chloroaromatic compounds by the action of Cl-MLEs. MLEs are members of the enolase superfamily characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and that is stabilized by coordination to the essential Mg2+ ion [PMID: 15581566, PMID: 8987982].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0018850 chloromuconate cycloisomerase activity
GO:0030145 manganese ion binding
GO:0018849 muconate cycloisomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.