SIAH-type domain (IPR013323)

Short name: SIAH-type

Domain relationships



The substrate-binding domain (SBD) of the SIAH (seven in absentia homolog) family of proteins is structurally highly similar to the TRAF domain. The SIAH SBD interacts with a number of proteins, and is involved in TNF-alpha-mediated NFkappaB activation [PMID: 11742346]. This entry represents the N-terminal portion of the SIAH substrate-binding domain, and the TRAF domain.

GO terms

Biological Process

GO:0016567 protein ubiquitination

Molecular Function

GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.