ABC transporter Tap-like (IPR013305)

Short name: ABC_Tap-like

Overlapping homologous superfamilies

Family relationships


The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [PMID: 11441126].

This entry includes Tap1/2 (transporter associated with antigen processing 1/2) and its homologue, Mdl2, from budding yeasts. They are a group of eukaryotic proteins belonging to the ABC transporter family. Tap proteins play a crucial role in the processing and presentation of the MHC class I-restricted antigens. Mdl2 is a mitochondrial inner membrane half-type ABC transporter that is required for respiratory growth at high temperature [PMID: 7912468, PMID: 11251115].

GO terms

Biological Process

GO:0015833 peptide transport

Molecular Function

GO:0005524 ATP binding
GO:1904680 peptide transmembrane transporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.