Neuropeptide B/W precursor family (IPR013297)

Short name: Neuropept_BW_pre

Overlapping homologous superfamilies


Family relationships


Two closely related neuropeptide precursors, which share no significant sequence similarity with other known neuropeptides, have recently been identified and named preproneuropeptide B and preproneuropeptide W [PMID: 12130646,PMID: 12401809,PMID: 12118011]. In humans, each precursor contains a signal sequence and two dibasic cleavage sites. Alternative cleavage of these sites results in long (29 or 30 amino acid) and short (23 amino acid) forms of the resultant neuropeptides [PMID: 12130646,PMID: 12401809]. Murine, rat and bovine versions of preproneuropeptide B, however, contain only the second cleavage site, resulting in only the long form of neuropeptide B [PMID: 12401809,PMID: 12118011]. Neuropeptide B is expressed in both the central nervous system (CNS) and in the periphery. In the CNS, the highest levels of the peptide are found in the substantia nigra and hypothalamus, suggesting a possible role in locomotor control and the release of pituitary hormones [PMID: 12401809]. In the periphery, the peptide is most abundant in testis, ovary, uterus, placenta, spleen, lymph nodes and peripheral blood leukocytes, indicating potential roles in the reproductive and immune systems [PMID: 12401809]. Unusually, neuropeptide B purified from bovine hypothalamus was found to be brominated at its N terminus [PMID: 12118011]. Neuropeptide W has a more limited distribution in the brain than neuropeptide B, and is found at highest levels in the substantia nigra, again suggesting an involvement in locomotor control [PMID: 12401809]. In the periphery, neuropeptide W is more widespread than neuropeptide B. In addition to the reproductive and immune tissues in which neuropeptide B is expressed, neuropeptide W has been found at high levels in the liver, stomach and trachea [PMID: 12401809]. Intracerebroventricular administration of neuropeptide W in rats has been reported to produce an acute increase in food intake and to stimulate prolactin release [PMID: 12130646].

This entry represents the neuropeptide B/W precursor family.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0001664 G protein-coupled receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.