Domain

Set2 Rpb1 interacting domain (IPR013257)

Short name: SRI

Overlapping homologous superfamilies

Domain relationships

None.

Description

The SRI (Set2 Rpb1 interacting) domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation [PMID: 15798214]. This domain is conserved from yeast to humans. Members of this family form a compact, closed three-helix bundle, with an up-down-up topology. The first and second helices are antiparallel to each other and are of similar length; the third helix, which is packed across helices alpha1 and alpha2 is slightly shorter, consisting of only 15 amino acids. Most conserved hydrophobic residues are largely buried in the interior of the structure and form an extensive and contiguous hydrophobic core that stabilises the packing of the three-helix bundle. This domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation [PMID: 16314571].

GO terms

Biological Process

GO:0034968 histone lysine methylation
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0018024 histone-lysine N-methyltransferase activity

Cellular Component

GO:0005694 chromosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam