Leader peptide, Arg-2/CPA1 (IPR013203)

Short name: Leader_Arg2_CPA1

Overlapping homologous superfamilies


Family relationships



In this family there are leader peptides involved in the regulation of the glutaminase subunit (small subunit) of arginine-specific carbamoyl phosphate synthetase. In Neurospora crassa it is a small upstream ORF of 24 codons above the arg-2 locus [PMID: 2141606]. In yeast it is the leader peptide of the CPA1 gene. The 5' region of CPA1 mRNA contains a 25 codon upstream open reading frame. The leader peptide, the product of the upstream open reading frame, plays an essential, negative role in the specific repression of CPA1 by arginine [PMID: 3555844].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.