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Overview
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Structures
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Cross-references
DASH complex subunit Hsk3-like (IPR013183)
Short name: Hsk3-like
Overlapping homologous superfamilies
None.
Family relationships
None.
Description
This entry includes Hsk3, Hos3 and Golgin-45.
Hsk3 is a subunit of the DASH complex, which is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [PMID: 11799062]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [PMID: 15640796, PMID: 15664196]. This family also includes several higher eukaryotic proteins. However, other DASH subunits do not appear to be conserved in higher eukaryotes.
Golgin-45 is required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. It interacts with GORASP2 and with the GTP-bound form of RAB2, but not with other Golgi Rab proteins [PMID: 11739401].
Hos3 (High osmolarity sensitivity protein 3) may play a role in the progression of mitosis in an environment of high osmotic stress [PMID: 10879493].
Contributing signatures
- PF08227 (DASH_Hsk3)