Family

DASH complex subunit Hsk3-like (IPR013183)

Short name: Hsk3-like

Family relationships

None.

Description

This entry includes Hsk3, Hos3 and Golgin-45.

Hsk3 is a subunit of the DASH complex, which is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [PMID: 11799062]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [PMID: 15640796, PMID: 15664196]. This family also includes several higher eukaryotic proteins. However, other DASH subunits do not appear to be conserved in higher eukaryotes.

Golgin-45 is required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. It interacts with GORASP2 and with the GTP-bound form of RAB2, but not with other Golgi Rab proteins [PMID: 11739401].

Hos3 (High osmolarity sensitivity protein 3) may play a role in the progression of mitosis in an environment of high osmotic stress [PMID: 10879493].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam