Histone acetyltransferase Rtt109/CBP (IPR013178)

Short name: Histone_AcTrfase_Rtt109/CBP

Overlapping homologous superfamilies


Family relationships


Histone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly. This family contains the fungal RTT109 protein, which is required for H3K56 acetylation [PMID: 17272723]. In Schizosaccharomyces pombe (Fission yeast) loss of RTT109 results in the loss of H3K56 acetylation, both on bulk histone and on chromatin [PMID: 17046836]. RTT109 and H3K56 acetylation appear to correlate with actively transcribed genes and associate with the elongating form of Pol II in yeast [PMID: 17046836]. This family also includes p300/CBP acetyltransferase, which has different catalytic properties and cofactor regulation to RTT109 [PMID: 18568037]. CREB-binding protein (CBP) is a transcriptional co-activator that acetylates both histones and non-histone proteins [PMID: 11359896, PMID: 15313412, PMID: 15313417]. CBP binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes [PMID: 11701890, PMID: 16287980].

GO terms

Biological Process

GO:0016573 histone acetylation
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0004402 histone acetyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.